Enzyme Structure/Function Analysis & Rational Molecular Design

With diverse natural enzyme, Hzymes has developed more than 20 kinds of enzyme molecular rational design approaches based on enzyme structure or function analysis to guarantee the efficiency of enzyme functioning.

Rational molecular design is a strategy of “creating new molecules with a certain functionality, based upon the ability to predict how the molecule’s structure will affect its behavior through physical models.” Using a three-dimensional structure along with the biophysical data and function of protein, rational molecular design applies site-directed mutagenesis to create new molecules with certain characteristics and functions.

Basic Workflow of Rational Design

Application of Rational Design

  • Decipher collagen stability
  • Map ligandreceptor interactions
  • Unveil protein folding and dynamics
  • Create extra-biological structures
  • Protein design
  • Nucleic acid design
  • Drug design
  • Pathway design

Advantages of Rational Design

  • An increased probability of beneficial mutations
  • A significant reduction of the library size
  • A reduction in the effort and time required for the screening of the library